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Comment
. 2014 Apr 3;14(4):423-4.
doi: 10.1016/j.stem.2014.03.011.

Tailor made protein synthesis for HSCs

Maria Barna  1 , Davide Ruggero  2
Affiliations
Comment

Tailor made protein synthesis for HSCs

Maria Barna et al. Cell Stem Cell. .

Abstract

Translation control is a prevalent form of gene expression regulation in developmental and stem cell biology. A recent paper by Signer et al. (2014) measures protein synthesis in the mouse hematopoietic compartment and reveals the importance of diminished protein production for maintaining hematopoietic stem cell function and restraining oncogenic potential.

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Figures

Figure 1
Figure 1. Impact of protein synthesis in progenitor cells and downstream oncogenic pathways
The Rpl24Bst/+ mouse is an important genetic tool to restore aberrant increases in protein synthesis downstream of oncogenic signaling in progenitor cells to normal levels. This reduction can suppress cancer formation downstream of Myc and PI3K-Akt-mTOR hyperactivation in B and T cell progenitors. Importantly, Signer et al. further show that restoring normal protein synthesis downstream loss of PTEN rescues HSC function and leukemogenesis. GOF: gain of function, LOF: loss of function.
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Comment on

References

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