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. 1988 May;52(2):151-60.
doi: 10.1111/j.1469-1809.1988.tb01091.x.

The human alpha-1-antitrypsin-related sequence gene: isolation and investigation of its expression

G D Kelsey  1 , M Parkar, S Povey
Affiliations

The human alpha-1-antitrypsin-related sequence gene: isolation and investigation of its expression

G D Kelsey et al. Ann Hum Genet. 1988 May.

Abstract

A genomic sequence approximately 5 kb in length designated the alpha-1-antitrypsin-related gene (ATR), showing considerable homology to the human alpha-1-antitrypsin (AAT) gene, was identified 10 kb downstream of the authentic AAT gene. The AAT and ATR genes were introduced separately into L-cells by transfection in order to establish a method for distinguishing between expression of the two genes. RNA probes from the cloned ATR region were then used in a ribonuclease protection assay against RNA from a range of human adult and fetal tissues. No evidence of expression of ATR was found, indicating that this region is probably a pseudogene.

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