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Comment
. 2014 Apr 1;19(4):549-50.
doi: 10.1016/j.cmet.2014.03.022.

Metabolism goes viral

Shigeki J Miyake-Stoner  1 , Clodagh C O'Shea  2
Affiliations
Comment

Metabolism goes viral

Shigeki J Miyake-Stoner et al. Cell Metab. .

Abstract

Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides for viral replication.

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Figures

Figure 1
Figure 1. Adenovirus oncoproteins reprogram cellular metabolism at multiple signaling and transcriptional nodes to induce a glycolytic shift that converts glucose into the molecular building blocks required for viral replication
Adenovirus E4ORF1 binds to MYC in the nucleus to activate the transcription of a subset of glycolytic target genes, HK2 and PFKM, that promote a Warburg-like shift to aerobic glycolysis. The activation of MYC, PI-3K and mTOR by E4-ORF1 and additional adenovirus oncoproteins could have emergent functions in reprogramming cellular metabolism to synthesize proteins and nucleic acids required for viral replication.
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References

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