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Comparative Study
. 1989 Apr 28;160(2):903-10.
doi: 10.1016/0006-291x(89)92520-5.

cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes

P Henttu  1 , P Vihko
Affiliations
Comparative Study

cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes

P Henttu et al. Biochem Biophys Res Commun. .

Abstract

We have isolated four cDNAs encoding the entire preproprotein of prostate specific antigen from human prostatic cDNA libraries. Comparison of the coding regions of prostate specific antigen with human pancreatic kallikrein (1-3) and human glandular kallikrein (4) showed 73%-84% nucleotide and 61-77% amino acid homologies, respectively, between these enzymes. Also the 3' noncoding regions of these genes were conserved. The close resemblance of prostate specific antigen, a marker for prostatic cancer, to glandular kallikrein suggests related immunogenic properties for them.

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