Promising small molecule for heart failure targeting adrenal catecholamine release and β-adrenergic receptor signaling in the heart

Jennifer L Hall¹, Timothy D O'Connell², Gary S Francis³

Affiliations

¹ Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota; Division of Cardiology, University of Minnesota, Minneapolis, Minnesota; Department of Medicine, University of Minnesota, Minneapolis, Minnesota. Electronic address: jlhall@umn.edu.
² Department of Integrative Physiology, University of Minnesota, Minneapolis, Minnesota.
³ Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota; Division of Cardiology, University of Minnesota, Minneapolis, Minnesota; Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

PMID: 24703911
DOI: 10.1016/j.jacc.2014.03.010

Free article

Editorial

Promising small molecule for heart failure targeting adrenal catecholamine release and β-adrenergic receptor signaling in the heart

Jennifer L Hall et al. J Am Coll Cardiol. 2014.

Free article

. 2014 Jun 17;63(23):2558-2559.

doi: 10.1016/j.jacc.2014.03.010. Epub 2014 Apr 2.

Authors

Jennifer L Hall¹, Timothy D O'Connell², Gary S Francis³

Affiliations

¹ Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota; Division of Cardiology, University of Minnesota, Minneapolis, Minnesota; Department of Medicine, University of Minnesota, Minneapolis, Minnesota. Electronic address: jlhall@umn.edu.
² Department of Integrative Physiology, University of Minnesota, Minneapolis, Minnesota.
³ Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota; Division of Cardiology, University of Minnesota, Minneapolis, Minnesota; Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

PMID: 24703911
DOI: 10.1016/j.jacc.2014.03.010

No abstract available

Keywords: catecholamines; heart failure; mice; small molecules; transverse aortic constriction; α(2)-adrenergic receptor; β-adrenergic receptor.

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Comment on

Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression.
Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. Kamal FA, et al. J Am Coll Cardiol. 2014 Jun 17;63(23):2549-2557. doi: 10.1016/j.jacc.2014.02.587. Epub 2014 Apr 2. J Am Coll Cardiol. 2014. PMID: 24703913 Free PMC article.

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Promising small molecule for heart failure targeting adrenal catecholamine release and β-adrenergic receptor signaling in the heart

Affiliations

Promising small molecule for heart failure targeting adrenal catecholamine release and β-adrenergic receptor signaling in the heart

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