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. 2013 Jul 1;4(3):334-57.
doi: 10.3390/genes4030334.

Roles of EphA2 in Development and Disease

Jeong Eun Park  1 , Alexander I Son  2 , Renping Zhou  3
Affiliations

Roles of EphA2 in Development and Disease

Jeong Eun Park et al. Genes (Basel). .

Abstract

The Eph family of receptor tyrosine kinases (RTKs) has been implicated in the regulation of many aspects of mammalian development. Recent analyses have revealed that the EphA2 receptor is a key modulator for a wide variety of cellular functions. This review focuses on the roles of EphA2 in both development and disease.

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Figures

Figure 1
Figure 1
Domain structure of EphA2 and the locations of human cataract mutations. LBD, ligand binding domain; C, cystein rich; FN-III, fibronectin type-III domain; TM, transmembrane domain; Kinase, protein tyrosine kinase domain; SAM, sterile alpha motif domain; P, PDZ-binding motif. Arrows indicate relative location of human cataract mutations.
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