C-H bond functionalization through intramolecular hydride transfer

Abstract

Known for over a century, reactions that involve intramolecular hydride-transfer events have experienced a recent resurgence. Undoubtedly responsible for the increased interest in this research area is the realization that hydride shifts represent an attractive avenue for C-H bond functionalization. The redox-neutral nature of these complexity-enhancing transformations makes them ideal for sustainable reaction development. This Review summarizes recent progress in this field while highlighting key historical contributions.

Keywords: CH functionalization; asymmetric catalysis; cascade reactions; hydride transfer; redox-neutral reactions.