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. 2014 Apr 18;16(8):2208-11.
doi: 10.1021/ol500723s. Epub 2014 Apr 7.

DMF as a source of oxygen and aminomethine: stereoselective 1,2-insertion of rhodium(II) azavinyl carbenes into the C═O bond of formamides for the synthesis of cis-diamino enones

Da Jung Jung  1 , Hyun Ji Jeon, Ju Hyun Kim, Youngmee Kim, Sang-gi Lee
Affiliations

DMF as a source of oxygen and aminomethine: stereoselective 1,2-insertion of rhodium(II) azavinyl carbenes into the C═O bond of formamides for the synthesis of cis-diamino enones

Da Jung Jung et al. Org Lett. .

Abstract

A new catalytic reaction in which all the atoms of a formamide are incorporated into the product through a formal stereoselective 1,2-insertion of rhodium(II) azavinyl carbenes, generated in situ from readily available N-sulfonylated 1,2,3-triazoles, into the C═O bond of DMF and other N,N-disubstituted formamides to afford cis-diamino enones is described.

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