Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2014 Mar;16(3):192-7.
doi: 10.1111/jch.12282. Epub 2014 Feb 20.

Left atrial enlargement in the early stage of hypertensive heart disease: a common but ignored condition

Guanhua Su  1 , Heng Cao, Sudan Xu, Yongxin Lu, Xinxin Shuai, Yufei Sun, Yuhua Liao, Jingdong Li
Affiliations
Comparative Study

Left atrial enlargement in the early stage of hypertensive heart disease: a common but ignored condition

Guanhua Su et al. J Clin Hypertens (Greenwich). 2014 Mar.

Abstract

How to identify the early signs of hypertensive heart disease is the key to block or reverse the process of heart failure. The aim of this study was to evaluate the predictive value of left atrial (LA) enlargement in the early stage of hypertensive heart disease and to explore the correlations between LA enlargement and heart failure with normal ejection fraction (HFnEF), as well as the metabolic syndrome (MetS). Baseline clinical characteristics, biochemical indices, electrocardiographic and echocardiographic data were collected from 341 consecutive patients with essential hypertension. Among those patients, LA enlargement was more frequently presented than LV enlargement (57.2% vs 17.9%). Compared with patients without HFnEF, the prevalence of LA enlargement was higher in patients with HFnEF (82.9% vs 49.0%, P<.0001). From grade 2 to grade 3 hypertension, LA size was significantly larger in patients with MetS (P<.01) than those without. Multivariate linear regression analyses showed that age, body mass index, waist circumference, triglyceride level, and left ventricular diameter were independent predictors of LA enlargement. The simple measurement for identification of LA enlargement potentially allows early recognition of those patients at risk for heart failure, particularly among patients with MetS.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The effect of metabolic syndrome (MS) on the relationship between level of hypertension and left atrial (LA) size.
See this image and copyright information in PMC

References

    1. Shigematsu Y, Norimatsu S, Ogimoto A, et al. The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients. Hypertens Res. 2009;32:500–504. - PubMed
    1. Tsang TS, Barnes ME, Gersh BJ, et al. Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden. Am J Cardiol. 2002;90:1284–1289. - PubMed
    1. Nicolaou VN, Papadakis JE, Karatzis EN, et al. Impact of the metabolic syndrome on atrial size in patients with new‐onset atrial fibrillation. Angiology. 2007;58:21–25. - PubMed
    1. Mancia G, Fagard R, Narkiewicz K, et al. 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2013;31:1925–1938. - PubMed
    1. Liu LS. [2010 Chinese guidelines for the management of hypertension]. Zhonghua Xin Xue Guan Bing Za Zhi. 2011;39:579–615. - PubMed

Publication types

MeSH terms