Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr 7:13:48.
doi: 10.1186/2251-6581-13-48. eCollection 2014.

Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study

Sohrab Halalkhor  1 , Farzad Jalali  2 , Karimollah Hajian Tilaki  3 , Shahla Shojaei  4
Affiliations

Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study

Sohrab Halalkhor et al. J Diabetes Metab Disord. .

Abstract

Background: Metabolic syndrome is an obesity dependent disorder with a worldwide high prevalence. Regarding the high prevalence of Metabolic syndrome in Iran we analyzed the influence of -1131T>C (rs662799) and c.56C>G (S19W, rs3135506) polymorphisms of the novel apolipoprotein gene, ApoA5, on some Metabolic Syndrome indicators in population from north of Iran.

Methods: 199 volunteers from Babol city-Iran were divided in two groups of low (N = 99, TG ≤ 103 mg/dl) and high (N = 100, TG ≥ 150 mg/dl) serum levels of Triglycerides (TG). We amplified the gene fragments containing -1131T>C and c.56C>G polymorphisms by PCR method and revealed the polymorphisms by RFLP analysis.

Results: We found a significant association (p = 0.016, Independent t-test) between high levels of TG and -1131T>C polymorphism but not between this polymorphism and serum HDL-C concentrations. Carriers of the C allele had a 1.97 times higher odds ratio to be in the high-TG group than those of the TT genotype (95%, CI = 1.05-3.68). We observed no association between -1131T>C polymorphism with either Waist-to-Hip Ratio (WHR) or Body-Mass-Index (BMI). In the case of c.56C>G polymorphism, although it showed a significant relationship with WHR (p = 0/040, Independent t-test), but failed to correlate with either levels of TG (p = 0.594) or HDL-C (p = 0.640) in serum.

Conclusion: Our study confirms that ApoA5 gene polymorphisms, -1131T>C and c.56C>G are associated with the two criteria of Metabolic Syndrome, TG and WHR, respectively.

Keywords: -1131T>C (rs662799); Triglyceride; WHR; c.56C>G (S19W; rs3135506).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Maps of the human APOA5 gene with polymorphism positions indicated. (A) Map of the human APOA5 gene. Exons 1-4 are numbered and represented by solid boxes. (B) Position of the single nucleotide polymorphism within the core promoter of the APOA5 gene, a T/C polymorphism at position -1131 and a C/G polymorphism at position 56.
See this image and copyright information in PMC

References

    1. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539–553. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. - DOI - PubMed
    1. Cifuentes-Goches JC, Gomez-Lopez Jde D, Hernandez-Ancheyta L, Flores-Fuentes SE, Inchaustegui-Arias JL, Canas-Urbina AO. [Hypertriglyceridemia and low HDL cholesterol as high impact factors for metabolic syndrome diagnosis in apparently healthy adults] Rev Med Inst Mex Seguro Soc. 2012;50:301–306. - PubMed
    1. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. Harrison's Principles of Internal Medicine. 18. McGraw Hill Professional; 2012.
    1. Wilson PW, D'Agostino RB, Parise H, Sullivan L, Meigs JB. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation. 2005;112:3066–3072. doi: 10.1161/CIRCULATIONAHA.105.539528. - DOI - PubMed
    1. Liu M, Wang J, Jiang B, Sun D, Wu L, Yang S, Wang Y, Li X, He Y. Increasing prevalence of metabolic syndrome in a chinese elderly population: 2001–2010. PLoS One. 2013;8:e66233. doi: 10.1371/journal.pone.0066233. - DOI - PMC - PubMed

LinkOut - more resources