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. 1988 Jul;8(7):2485-90.
doi: 10.1523/JNEUROSCI.08-07-02485.1988.

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

D Giulian  1 , J Woodward, D G Young, J F Krebs, L B Lachman
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Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

D Giulian et al. J Neurosci. 1988 Jul.

Abstract

Interleukin-1 (IL-1), a protein produced by mononuclear phagocytes, helps to initiate the inflammatory response through its action upon a diverse population of cells. Recently this immunomodulator has been detected at sites of traumatized brain. As reported here, recombinant forms of IL-1 injected into the cerebral cortex of adult rats elicit not only astrogliosis but also new blood vessel growth. These responses are typical of brain injury and suggest that IL-1-secreting inflammatory cells may mediate wound healing in the CNS.

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