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. 2014 Apr 7;9(4):e93992.
doi: 10.1371/journal.pone.0093992. eCollection 2014.

Postoperative hypoxia and length of intensive care unit stay after cardiac surgery: the underweight paradox?

Marco Ranucci  1 , Andrea Ballotta  1 , Maria Teresa La Rovere  2 , Serenella Castelvecchio  1 ; Surgical and Clinical Outcome Research (SCORE) Group
Affiliations

Postoperative hypoxia and length of intensive care unit stay after cardiac surgery: the underweight paradox?

Marco Ranucci et al. PLoS One. .

Abstract

Objective: Cardiac operations with cardiopulmonary bypass can be associated with postoperative lung dysfunction. The present study investigates the incidence of postoperative hypoxia after cardiac surgery, its relationship with the length of intensive care unit stay, and the role of body mass index in determining postoperative hypoxia and intensive care unit length of stay.

Design: Single-center, retrospective study.

Setting: University Hospital. Patients. Adult patients (N = 5,023) who underwent cardiac surgery with CPB.

Interventions: None.

Measurements and main results: According to the body mass index, patients were attributed to six classes, and obesity was defined as a body mass index >30. POH was defined as a PaO2/FiO2 ratio <200 at the arrival in the intensive care unit. Postoperative hypoxia was detected in 1,536 patients (30.6%). Obesity was an independent risk factor for postoperative hypoxia (odds ratio 2.4, 95% confidence interval 2.05-2.78, P = 0.001) and postoperative hypoxia was a determinant of intensive care unit length of stay. There is a significant inverse correlation between body mass index and PaO2/FiO2 ratio, with the risk of postoperative hypoxia increasing by 1.7 folds per each incremental body mass index class. The relationship between body mass index and intensive care unit length of stay is U-shaped, with longer intensive care unit stay in underweight patients and moderate-morbid obese patients.

Conclusions: Obese patients are at higher risk for postoperative hypoxia, but this leads to a prolonged intensive care unit stay only for moderate-morbid obese patients. Obese patients are partially protected against the deleterious effects of hemodilution and transfusions. Underweight patients present the "paradox" of a better lung gas exchange but a longer intensive care unit stay. This is probably due to a higher severity of their cardiac disease.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Univariate association between PaO2/FiO2 ratio at the arrival in the intensive care unit (ICU) and ICU length of stay.
Grey area is 95% confidence interval.
Figure 2
Figure 2. Univariate association between body mass index and PaO2/FiO2 ratio at the arrival in the intensive care.
Grey area is 95% confidence interval. Boxes represent the six body mass index classes, with the median (line through the box), the interquartile range (box) and the 5% and 95% centiles (whiskers).
Figure 3
Figure 3. Univariate association between body mass index and intensive care unit (ICU) stay.
Grey area is 95% confidence interval. Boxes represent the six body mass index classes, with the median (line through the box), the interquartile range (box) and the 5% and 95% centiles (whiskers).
See this image and copyright information in PMC

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