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. 2012 Nov 5;1(4):994-1009.
doi: 10.3390/cells1040994.

Human stem cells and articular cartilage regeneration

Affiliations

Human stem cells and articular cartilage regeneration

Atsuyuki Inui et al. Cells. .

Abstract

The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells, scaffolds and signals, including morphogens and growth factors. Stem cells, as a source of cells for articular cartilage regeneration, are a critical factor for articular cartilage regeneration. This is because articular cartilage tissue has a low cell turnover and does not heal spontaneously. Adult stem cells have been isolated from various tissues, such as bone marrow, adipose, synovial tissue, muscle and periosteum. Signals of the transforming growth factor beta superfamily play critical roles in chondrogenesis. However, adult stem cells derived from various tissues tend to differ in their chondrogenic potential. Pluripotent stem cells have unlimited proliferative capacity compared to adult stem cells. Chondrogenesis from embryonic stem (ES) cells has been studied for more than a decade. However, establishment of ES cells requires embryos and leads to ethical issues for clinical applications. Induced pluripotent stem (iPS) cells are generated by cellular reprogramming of adult cells by transcription factors. Although iPS cells have chondrogenic potential, optimization, generation and differentiation toward articular chondrocytes are currently under intense investigation.

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References

    1. Heng B.C., Cao T., Lee E.H. Directing stem cell differentiation into the chondrogenic lineage in vitro . Stem Cells. 2004;22:1152–1167. doi: 10.1634/stemcells.2004-0062. - DOI - PubMed
    1. Wei Y., Zeng W., Wan R., Wang J., Zhou Q., Qiu S., Singh S.R. Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix. Eur. Cell. Mater. 2012;23:1–12. - PMC - PubMed
    1. Lohmander L.S., Roos E.M. Clinical update: Treating osteoarthritis. Lancet. 2007;370:2082–2084. doi: 10.1016/S0140-6736(07)61879-0. - DOI - PubMed
    1. Smith G.D., Knutsen G., Richardson J.B. A clinical review of cartilage repair techniques. J. Bone Joint. Surg. Br. 2005;87:445–449. doi: 10.1302/0301-620X.87B4.15971. - DOI - PubMed
    1. Okamoto Y., Nakagawa Y., Maekawa M., Kobayashi M., Nakamura T. Osteochondral grafting for treatment of a massive chondral defect in the knee of a young adult with anterior cruciate ligament deficit. Arthroscopy. 2007;1024:e1021–e1024. - PubMed