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. 2012 Nov 12;1(4):1061-88.
doi: 10.3390/cells1041061.

Mesenchymal stem or stromal cells from amnion and umbilical cord tissue and their potential for clinical applications

Andrea Lindenmair  1 , Tim Hatlapatka  2 , Gregor Kollwig  3 , Simone Hennerbichler  4 , Christian Gabriel  5 , Susanne Wolbank  6 , Heinz Redl  7 , Cornelia Kasper  8
Affiliations

Mesenchymal stem or stromal cells from amnion and umbilical cord tissue and their potential for clinical applications

Andrea Lindenmair et al. Cells. .

Abstract

Mesenchymal stem or stromal cells (MSC) have proven to offer great promise for cell-based therapies and tissue engineering applications, as these cells are capable of extensive self-renewal and display a multilineage differentiation potential. Furthermore, MSC were shown to exhibit immunomodulatory properties and display supportive functions through parakrine effects. Besides bone marrow (BM), still today the most common source of MSC, these cells were found to be present in a variety of postnatal and extraembryonic tissues and organs as well as in a large variety of fetal tissues. Over the last decade, the human umbilical cord and human amnion have been found to be a rich and valuable source of MSC that is bio-equivalent to BM-MSC. Since these tissues are discarded after birth, the cells are easily accessible without ethical concerns.

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Figures

Figure 1
Figure 1
Different techniques used during isolation of mesenchymal stem or stromal cells (MSC) from umbilical cord (UC) tissue. Basically enzymatic digestion or explant culture approaches are used.
Figure 2
Figure 2
Primary UC-derived cell cultures can contain broad cell size distributions (I < II < III).
See this image and copyright information in PMC

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