Alzheimer's disease in African Americans: risk factors and challenges for the future
- PMID: 24711318
- PMCID: PMC4084964
- DOI: 10.1377/hlthaff.2013.1353
Alzheimer's disease in African Americans: risk factors and challenges for the future
Abstract
As the US elderly population continues to expand rapidly, Alzheimer's disease poses a major and increasing public health challenge, and older African Americans may be disproportionately burdened by the disease. Although African Americans were generally underincluded in previous research studies, new and growing evidence suggests that they may be at increased risk of the disease and that they differ from the non-Hispanic white population in risk factors and disease manifestation. This article offers an overview of the challenges of Alzheimer's disease in African Americans, including diagnosis issues, disparities in risk factors and clinical presentation of disease, and community-based recommendations to enhance research with this population.
Keywords: Disparities; Elderly; Epidemiology; Minority Health.
Similar articles
-
Racial and Ethnic Disparities in Serious Psychological Distress Among Those With Alzheimer's Disease and Related Dementias.Am J Geriatr Psychiatry. 2020 Apr;28(4):478-490. doi: 10.1016/j.jagp.2019.08.010. Epub 2019 Aug 15. Am J Geriatr Psychiatry. 2020. PMID: 31500897 Free PMC article.
-
Dementia in older minority populations. Issues of prevalence, diagnosis, and treatment.Am J Geriatr Psychiatry. 1998 Spring;6(2 Suppl 1):S19-25. doi: 10.1097/00019442-199821001-00003. Am J Geriatr Psychiatry. 1998. PMID: 9581217 Review.
-
Perspective on the "African American participation in Alzheimer disease research: Effective strategies" workshop, 2018.Alzheimers Dement. 2020 Dec;16(12):1734-1744. doi: 10.1002/alz.12160. Epub 2020 Aug 17. Alzheimers Dement. 2020. PMID: 33034414 Free PMC article.
-
Alzheimer's Disease and Alzheimer's Disease-Related Dementias in Older African American and White Veterans.J Alzheimers Dis. 2020;75(1):311-320. doi: 10.3233/JAD-191188. J Alzheimers Dis. 2020. PMID: 32280090 Free PMC article.
-
The role of social and behavioral risk factors in explaining racial disparities in age-related cognitive impairment: a structured narrative review.Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2020 Mar;27(2):173-196. doi: 10.1080/13825585.2019.1598539. Epub 2019 Apr 6. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2020. PMID: 30955411 Review.
Cited by
-
Association between anti-inflammatory interleukin-10 and executive function in African American women at risk for Alzheimer's disease.J Clin Exp Neuropsychol. 2020 Sep;42(7):647-659. doi: 10.1080/13803395.2020.1798879. Epub 2020 Aug 11. J Clin Exp Neuropsychol. 2020. PMID: 32781877 Free PMC article.
-
Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial.Front Aging Neurosci. 2023 Nov 21;15:1266423. doi: 10.3389/fnagi.2023.1266423. eCollection 2023. Front Aging Neurosci. 2023. PMID: 38076534 Free PMC article.
-
Underrepresentation of African-Americans in Alzheimer's Trials: A Call for Affirmative Action.Front Aging Neurosci. 2016 Jun 3;8:123. doi: 10.3389/fnagi.2016.00123. eCollection 2016. Front Aging Neurosci. 2016. PMID: 27375473 Free PMC article. No abstract available.
-
The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer's Disease Risk in African Americans: A Focused Mini Review.Front Hum Neurosci. 2019 Nov 5;13:387. doi: 10.3389/fnhum.2019.00387. eCollection 2019. Front Hum Neurosci. 2019. PMID: 31749691 Free PMC article.
-
Exercise Effects on Cognition in Older African Americans: A Pilot Randomized Trial.Front Aging Neurosci. 2022 Jul 22;14:921978. doi: 10.3389/fnagi.2022.921978. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35936770 Free PMC article.
References
-
- Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):280–92. - PMC - PubMed
-
- Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–9. - PMC - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials