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Comment
. 2014 Jun;82(6):2160-1.
doi: 10.1128/IAI.01830-14. Epub 2014 Apr 7.

Lipid a is more than acyl chains

Michael A Apicella  1
Affiliations
Comment

Lipid a is more than acyl chains

Michael A Apicella. Infect Immun. 2014 Jun.

Abstract

The acyl chain length, number, and distribution have been considered the major factors contributing to this biological activity of lipid A. The charged head groups on the dihexosamine backbone have also been implicated in contributing to this biology. In Neisseria, it has now been shown that loss of the 4' phosphoethanolamine has an impact on virulence in an animal model and on the organism's susceptibility to cationic antimicrobial peptides. Such studies offer potential insight into targets for novel antimicrobial agents.

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References

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