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. 2013 Apr;9(4):252-4.

Immunoglobulin g4-associated cholangitis can mimic cholangiocarcinoma on radiologic and cholangioscopic findings

Susana Gonzalez  1 , Roger Klein Moreira  2 , Elizabeth C Verna  3 , Benjamin Samstein  3 , John M Poneros  4
Affiliations

Immunoglobulin g4-associated cholangitis can mimic cholangiocarcinoma on radiologic and cholangioscopic findings

Susana Gonzalez et al. Gastroenterol Hepatol (N Y). 2013 Apr.
No abstract available

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Figures

Figure 1
Figure 1
This coronal T2 magnetic resonance image shows dilation of the intrahepatic biliary ducts and an amorphous, heterogeneous signal abnormality at the confluence of the right and left hepatic ducts.
Figure 2
Figure 2
A SpyGlass cholangioscopy image (right) and endoscopic view (left) showing irregular mucosa with dilated and tortuous vessels and papillary-appearing mucosal projections.
Figure 3
Figure 3
A segment of bile duct shows marked periductal chronic inflammation near the area of stricture (hematoxylin and eosin stain, 100x magnification).
Figure 4
Figure 4
A: This higher magnification of periductal inflammatory infiltrate shows sheets of plasma cells (hematoxylin and eosin [H and E] stain, 400x magnification). B: This immunohistochemistry slide shows strong immunoglobulin G4 expression by the majority of plasma cells (H and E stain, 400x magnification).
See this image and copyright information in PMC

References

    1. Ghazale A, Chari ST, Zhang L, et al. Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy. Gastroenterology. 2008;134:706–715. - PubMed
    1. Hamano H, Kawa S, Uehara T, et al. Immunoglobulin G4-related lymphoplasmacytic sclerosing cholangitis that mimics infiltrating hilar cholangiocarcinoma: part of a spectrum of autoimmune pancreatitis? Gastrointest Endosc. 2005;62:152–157. - PubMed
    1. Nakazawa T, Ando T, Hayashi K, Naitoh I, Ohara H, Joh T. Diagnostic procedures for IgG4-related sclerosing cholangitis. J Hepatobiliary Pancreat Sci. 2011;18:127–136. - PubMed
    1. Nakazawa T, Naitoh I, Hayashi K, et al. Diagnostic criteria for IgG4-related sclerosing cholangitis based on cholangiographic classification. J Gastroenterol. 2012;47:79–87. - PubMed
    1. Oh HC, Kim MH, Lee KT, et al. Clinical clues to suspicion of IgG4-associated sclerosing cholangitis disguised as primary sclerosing cholangitis or hilar cholangiocarcinoma. J Gastroenterol Hepatol. 2010;25:1831–1837. - PubMed

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