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. 2014:2014:582016.
doi: 10.1155/2014/582016. Epub 2014 Feb 23.

Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML

Cigdem Aydin  1 , Zafer Cetin  1 , Ozan Salim  2 , Orhan Kemal Yucel  2 , Levent Undar  2 , Sibel Berker Karauzum  1
Affiliations

Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML

Cigdem Aydin et al. Case Rep Genet. 2014.

Abstract

Chronic myelogenous leukemia (CML) is a clonal hematological disorder, which is characterized by the presence of the classical or variant Philadelphia translocations. During the progression to blastic phase of the disease secondary chromosomal abnormalities may emerge. Such secondary chromosomal abnormalities are nonrandom, the more frequent ones being trisomy 8 and 19, supernumerary i(17q), and extra Philadelphia chromosomes. Furthermore, a minor percentage of the patients may acquire different secondary chromosomal abnormalities including translocations between other chromosomes. We report here a patient with Ph+ CML presenting secondary chromosomal abnormalities including t(4;11)(q21;q23), t(3;3)(q29;q23) and t(11;18)(q10;q10) during the course of CML progression.

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Figures

Figure 1
Figure 1
Karyotype of the bone marrow cells evaluated in 2012.
Figure 2
Figure 2
An interphase cell having a secondary Philadelphia chromosome detected in 2012.
See this image and copyright information in PMC

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