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Editorial
. 2014 Mar;59(3):754-6.
doi: 10.1002/hep.26682.

Autoimmune hepatitis: 50 Years of (slow) progress

M Eric Gershwin, Edward L Krawitt
Editorial

Autoimmune hepatitis: 50 Years of (slow) progress

M Eric Gershwin et al. Hepatology. 2014 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Genetic and environmental factors influence the dysregulation of the immune response and contribute to the predisposition for AIH. CD39pos Tregs from AIH patients reflect a decrease in cell number, skewed subset phenotype, and impaired ectonucleotidase activity. This leads to defective IL17 suppression and T cell proliferation suppression. Lastly, there is an increased rate of conversion of the CD39pos Tregs to IL17, INFγ secreting effector cells.
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References

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