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. 2014 Apr 9;136(14):5257-60.
doi: 10.1021/ja501621q. Epub 2014 Mar 31.

Decarboxylative arylation of α-amino acids via photoredox catalysis: a one-step conversion of biomass to drug pharmacophore

Zhiwei Zuo  1 , David W C MacMillan
Affiliations

Decarboxylative arylation of α-amino acids via photoredox catalysis: a one-step conversion of biomass to drug pharmacophore

Zhiwei Zuo et al. J Am Chem Soc. .

Abstract

The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.

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Figures

Scheme 1
Scheme 1. Proposed Catalytic Cycle for Decarboxylative Arylation
See this image and copyright information in PMC

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