Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis

Egil Røsjø¹, Kjell-Morten Myhr², Kristin Ingeleiv Løken-Amsrud³, Søren Jacob Bakke⁴, Antonie G Beiske⁵, Kristian S Bjerve⁶, Harald Hovdal⁷, Finn Lilleås⁸, Rune Midgard⁹, Tom Pedersen¹⁰, Jūratė Saltytė Benth¹¹, Øivind Torkildsen¹², Stig Wergeland¹², Annika E Michelsen¹³, Pål Aukrust¹⁴, Thor Ueland¹³, Trygve Holmøy¹⁵

Affiliations

¹ Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: egil.rorvik.rosjo@ahus.no.
² Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
³ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway.
⁴ Department of Neuroradiology, Oslo University Hospital, Oslo, Norway.
⁵ Multiple Sclerosis Centre Hakadal, Hakadal, Norway.
⁶ Department of Medical Biochemistry, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children´s and Women´s Health, Norwegian University of Science and Technology, Trondheim, Norway.
⁷ Department of Neurology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
⁸ Curato Oslo, Oslo, Norway.
⁹ Department of Neurology, Molde Hospital, Molde, Norway; Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway.
¹⁰ Unilabs Drammen, Drammen, Norway.
¹¹ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Helse Sør-Øst Health Services Research Centre, Akershus University Hospital, Lørenskog, Norway.
¹² Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
¹³ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
¹⁴ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway.
¹⁵ Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

PMID: 24713402
DOI: 10.1016/j.jneuroim.2014.03.014

Randomized Controlled Trial

Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis

Egil Røsjø et al. J Neuroimmunol. 2014.

. 2014 Jun 15;271(1-2):60-5.

doi: 10.1016/j.jneuroim.2014.03.014. Epub 2014 Mar 24.

Authors

Affiliations

¹ Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: egil.rorvik.rosjo@ahus.no.
² Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
³ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway.
⁴ Department of Neuroradiology, Oslo University Hospital, Oslo, Norway.
⁵ Multiple Sclerosis Centre Hakadal, Hakadal, Norway.
⁶ Department of Medical Biochemistry, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children´s and Women´s Health, Norwegian University of Science and Technology, Trondheim, Norway.
⁷ Department of Neurology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
⁸ Curato Oslo, Oslo, Norway.
⁹ Department of Neurology, Molde Hospital, Molde, Norway; Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway.
¹⁰ Unilabs Drammen, Drammen, Norway.
¹¹ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Helse Sør-Øst Health Services Research Centre, Akershus University Hospital, Lørenskog, Norway.
¹² Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
¹³ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
¹⁴ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway.
¹⁵ Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

PMID: 24713402
DOI: 10.1016/j.jneuroim.2014.03.014

Abstract

To explore the relationships between vitamin A, D and E and inflammation in relapsing remitting multiple sclerosis, we assessed their associations with 11 inflammation markers in 9 serial serum samples from 85 patients, before and during interferon-β1a treatment. A negative association was found between vitamin A and pentraxin 3 independent of interferon-β1a use, whereas positive associations between vitamin D and interleukin-1 receptor antagonist and secreted frizzled-related protein 3 were seen before, and between vitamin E and chemokine (C-X-C motif) ligand 16 during interferon-β1a treatment. These findings suggest associations with diverse inflammatory pathways, which may be differentially influenced by interferon-β1a treatment.

Keywords: Inflammation; Multiple sclerosis; Vitamin A; Vitamin D; Vitamin E.

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Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis

Affiliations

Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis

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Abstract

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