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. 2014 Aug;67(8):571-5.
doi: 10.1038/ja.2014.37. Epub 2014 Apr 9.

Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46

Xiachang Wang  1 , Khaled A Shaaban  1 , Sherif I Elshahawi  1 , Larissa V Ponomareva  1 , Manjula Sunkara  2 , Gregory C Copley  3 , James C Hower  3 , Andrew J Morris  2 , Madan K Kharel  4 , Jon S Thorson  1
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Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46

Xiachang Wang et al. J Antibiot (Tokyo). 2014 Aug.

Abstract

Two new cyclopeptides, mullinamides A [cyclo-(-L-Gly-L-Glu-L-Val-L-Ile-L-Pro-)] and B [cyclo-(-L-Glu-L-Met-L-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [cyclo-(-L-Ile-D-Ile-L-Lys-L-Ile-D-Phe-D-Leu-L-Ile-D-Ala-)], cyclo-(-L-Pro-L-Phe-) and cyclo-(-L-Pro-L-Leu-). The structures of the new compounds were elucidated by the cumulative analyses of NMR spectroscopy and HRMS. Although mullinamides A and B displayed no appreciable antimicrobial/fungal activity or cytotoxicity, this study highlights the first reported antibacterial activity of surugamide A.

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Figures

Figure 1
Figure 1
Structures of compounds isolated from Streptomyces sp. RM-27–46.
Figure 2
Figure 2
1H,1H-COSY (▬) and selected HMBC (→) correlations of mullinamides A (1) and B (2).
See this image and copyright information in PMC

References

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