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Comment
. 2014 Apr 8;12(4):e1001834.
doi: 10.1371/journal.pbio.1001834. eCollection 2014 Apr.

A novel regulatory T cell population in the gut

Caitlin Sedwick  1
Affiliations
Comment

A novel regulatory T cell population in the gut

Caitlin Sedwick. PLoS Biol. .
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

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In the colonic mucosa, antigens of Faecalibacterium prausnitzii (a clostridium bacteria from the gut microbiota) are presented by dendritic cells. Recognition of these antigens by the CD4 T cells equipped with a specific TCR contributes to their differentiation into FoxP3-lacking regulatory T cells (Treg) characterized by the co-expression of CD4 and CD8α. Most of these Treg stay in the colonic mucosa where they prevent excessive inflammatory responses. A fraction of them migrate into the blood, likely contributing to the immune tolerance outside the gut.
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