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. 2014 Apr 8;11(4):e1001616.
doi: 10.1371/journal.pmed.1001616. eCollection 2014 Apr.

HIV monoclonal antibodies: a new opportunity to further reduce mother-to-child HIV transmission

Yegor Voronin  1 , Lynne M Mofenson  2 , Coleen K Cunningham  3 , Mary G Fowler  4 , Pontiano Kaleebu  5 , Elizabeth J McFarland  6 , Jeffrey T Safrit  7 , Barney S Graham  8 , William Snow  1
Affiliations

HIV monoclonal antibodies: a new opportunity to further reduce mother-to-child HIV transmission

Yegor Voronin et al. PLoS Med. .

Abstract

Yegor Voronin and colleagues explore how monoclonal antibodies against HIV could provide a new opportunity to further reduce mother-to-child transmission of HIV and propose that new interventions should consider issues related to implementation, feasibility, and access. Please see later in the article for the Editors' Summary.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. While 77% of women in sub-Saharan Africa have at least one antenatal care (ANC) visit, most are not seen until the second or third trimester .
In contrast, the majority of women in the United States access antenatal care during the first trimester .
Figure 2
Figure 2. One possible clinical pathway for testing monoclonal antibodies in infants.
Safety, pharmacokinetics (PK), and biological effect on virus populations are initially assessed in HIV-positive adults. Dosing is further refined in studies in HIV-negative adults and infants. This information is used to design an efficacy study in HIV-exposed infants as an adjunct to standard ARV treatment and prophylaxis.
See this image and copyright information in PMC

References

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