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Review
. 2013;26(2):100-103.

Role of non-acid reflux in patients with non-erosive reflux disease

Georgios P Karamanolis  1 , Radu Tutuian  2
Affiliations
Review

Role of non-acid reflux in patients with non-erosive reflux disease

Georgios P Karamanolis et al. Ann Gastroenterol. 2013.

Abstract

Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux episodes is of importance in evaluating the results of combined pH-impedance monitoring in NERD patients. Mucosal hypersensitivity and mechanical stimulation due to great volume of non-acid reflux are among the putative mechanisms of symptom generation.

Keywords: Non-acid reflux; non-erosive reflux disease.

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Conflict of interest statement

Conflict of Interest: None

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