Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988;62(6):479-81.
doi: 10.1007/BF00288355.

Relative induction of molecular forms of cytochrome P-450 in gamma-hexachlorocyclohexane exposed rat liver microsomes

A Kumar  1 , P P Dwivedi
Affiliations

Relative induction of molecular forms of cytochrome P-450 in gamma-hexachlorocyclohexane exposed rat liver microsomes

A Kumar et al. Arch Toxicol. 1988.

Abstract

The effect of gamma-hexachlorocyclohexane (HCH), (25 mg/kg body weight, i.p., administered for 4 consecutive days) on the induction of types of cytochrome P-450 in rat liver microsomes was studied. Induced proteins were characterized by "Western" blot analysis, using anticytochrome P-450 antibodies. It was observed that HCH is a "mixed-type" inducer and mediates induction of cytochrome P-450 b/e forms by several fold and of cytochrome P-450 c and d forms by nearly three fold.

PubMed Disclaimer

References

    1. Chem Biol Interact. 1973 May;6(5):307-16 - PubMed
    1. J Biochem Toxicol. 1986 Jun;1(2):95-107 - PubMed
    1. Drug Metab Dispos. 1977 Jan-Feb;5(1):1-8 - PubMed
    1. J Biol Chem. 1983 Sep 25;258(18):11280-4 - PubMed
    1. CRC Crit Rev Toxicol. 1974 Sep;3(1):97-158 - PubMed

Publication types

LinkOut - more resources