doi: 10.1042/bj2590905.
Inhibition of aspartic proteinases by alpha 2-macroglobulin
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- PMID: 2471514
- PMCID: PMC1138603
- DOI: 10.1042/bj2590905
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Inhibition of aspartic proteinases by alpha 2-macroglobulin
Biochem J.
.
Abstract
The effect of alpha 2-macroglobulin, one of the major antiproteinases in the plasma of vertebrates, on the action of the aspartic proteinases chymosin, cathepsin D and cathepsin E towards peptide and protein substrates at pH 6.2 was examined. Activities towards protein substrates were blocked, thus demonstrating that alpha 2-macroglobulin can inhibit aspartic proteinases, in addition to serine proteinases, cysteine proteinases and metalloproteinases.
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