Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr 9:11:68.
doi: 10.1186/1743-422X-11-68.

Prospective study of Hepatitis E Virus infection among pregnant women in France

Christophe Renou, Vincent Gobert, Christophe Locher, Abdelouahab Moumen, Oumar Timbely, Janine Savary, Anne-Marie Roque-Afonso  1 ; Association Nationale des Hépato-Gastroentérologues des Hôpitaux Généraux (ANGH)
Affiliations

Prospective study of Hepatitis E Virus infection among pregnant women in France

Christophe Renou et al. Virol J. .

Abstract

Background: Hepatitis E Virus (HEV) infection has a poor prognosis among pregnant women from high endemic countries. HEV-prevalence and incidence among pregnant women is unknown in high-income countries such as France. This prospective study was conducted to assess HEV infection in this setting.

Findings: An overall HEV prevalence of 7.74% was observed among 315 pregnant women. Seroprevalence was higher in south than in north of France (29.3% vs. 3.6%, p < 0.0001), and women with detectable IgG were older. No IgG seroconversion or IgM detection were observed during pregnancy.

Conclusions: Data suggest that HEV infection is a rare occurrence during pregnancy even in regions of western countries with high seroprevalence rates.

PubMed Disclaimer

References

    1. Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J, Dalton HR. Hepatitis E. Lancet. 2012;379(9835):2477–2488. doi: 10.1016/S0140-6736(11)61849-7. - DOI - PubMed
    1. Rein DB, Stevens GA, Theaker J, Wittenborn JS, Wiersma ST. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology. 2012;55(4):988–997. doi: 10.1002/hep.25505. - DOI - PubMed
    1. Andersson MI, Hughes J, Gordon FH, Ijaz S, Donati M. Of pigs and pregnancy. Lancet. 2008;372(9644):1192. doi: 10.1016/S0140-6736(08)61486-5. - DOI - PubMed
    1. Anty R, Ollier L, Peron JM, Nicand E, Cannavo I, Bongain A, Giordanengo V, Tran A. First case report of an acute genotype 3 hepatitis E infected pregnant woman living in South-Eastern France. J Clin Virol. 2012;54(1):76–78. doi: 10.1016/j.jcv.2012.01.016. - DOI - PubMed
    1. Mansuy JM, Legrand-Abravanel F, Calot JP, Peron JM, Alric L, Agudo S, Rech H, Destruel F, Izopet J. High prevalence of anti-hepatitis E virus antibodies in blood donors from South West France. J Med Virol. 2008;80(2):289–293. doi: 10.1002/jmv.21056. - DOI - PubMed

Publication types