The phylogenetics of dynamics in DNA clamp proteins
- PMID: 24717558
- DOI: 10.1016/j.str.2014.03.006
The phylogenetics of dynamics in DNA clamp proteins
Abstract
Using HXMS to measure protein dynamics, Fang and colleagues (in this issue of Structure) probe the dynamics of processivity clamp proteins from all kingdoms of life. The proteins have similar structures but divergent sequences. Their results show conserved dynamics correlating with primary functions and divergent dynamics for divergent functions.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Comment on
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Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics.Structure. 2014 Apr 8;22(4):572-581. doi: 10.1016/j.str.2014.02.001. Epub 2014 Mar 6. Structure. 2014. PMID: 24613485 Free PMC article.
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