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. 2014 Apr 9;106(5):dju068.
doi: 10.1093/jnci/dju068.

Dietary fat intake and development of specific breast cancer subtypes

Sabina Sieri  1 , Paolo Chiodini  1 , Claudia Agnoli  1 , Valeria Pala  1 , Franco Berrino  1 , Antonia Trichopoulou  1 , Vassiliki Benetou  1 , Effie Vasilopoulou  1 , María-José Sánchez  1 , Maria-Dolores Chirlaque  1 , Pilar Amiano  1 , J Ramón Quirós  1 , Eva Ardanaz  1 , Genevieve Buckland  1 , Giovanna Masala  1 , Salvatore Panico  1 , Sara Grioni  1 , Carlotta Sacerdote  1 , Rosario Tumino  1 , Marie-Christine Boutron-Ruault  1 , Françoise Clavel-Chapelon  1 , Guy Fagherazzi  1 , Petra H M Peeters  1 , Carla H van Gils  1 , H Bas Bueno-de-Mesquita  1 , Henk J van Kranen  1 , Timothy J Key  1 , Ruth C Travis  1 , Kay Tee Khaw  1 , Nicholas J Wareham  1 , Rudolf Kaaks  1 , Annekatrin Lukanova  1 , Heiner Boeing  1 , Madlen Schütze  1 , Emily Sonestedt  1 , Elisabeth Wirfält  1 , Malin Sund  1 , Anne Andersson  1 , Veronique Chajes  1 , Sabina Rinaldi  1 , Isabelle Romieu  1 , Elisabete Weiderpass  1 , Guri Skeie  1 , Engeset Dagrun  1 , Anne Tjønneland  1 , Jytte Halkjær  1 , Kim Overvard  1 , Melissa A Merritt  1 , David Cox  1 , Elio Riboli  1 , Vittorio Krogh  1
Affiliations

Dietary fat intake and development of specific breast cancer subtypes

Sabina Sieri et al. J Natl Cancer Inst. .

Abstract

We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.

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