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Review
. 2015 Mar;66(3):204-10.
doi: 10.1177/0003319714530040. Epub 2014 Apr 8.

Trimetazidine and cardioprotection: facts and perspectives

Konstantinos Tsioufis  1 , George Andrikopoulos  2 , Athanasios Manolis  3
Affiliations
Review

Trimetazidine and cardioprotection: facts and perspectives

Konstantinos Tsioufis et al. Angiology. 2015 Mar.

Abstract

Trimetazidine (TMZ) is a metabolic agent used in cardiology for more than 40 years. Several studies assessed the cardioprotective effects of TMZ in patients with chronic coronary heart disease (CHD) as well as in patients with heart failure (HF). In light of the inclusion of TMZ in the current guidelines on the management of stable CHD, we reviewed the published literature on TMZ, focusing mainly its effects on patients with stable angina and HF. According to the published literature, there is sufficient evidence to support the addition of this agent in the treatment of symptomatic patients with stable angina.

Keywords: coronary heart disease; heart failures; stable angina; trimetazidine.

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