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. 2014 Oct;30(10):951-68.
doi: 10.1002/cnm.2638. Epub 2014 Apr 9.

Strategy for analysis of flow diverting devices based on multi-modality image-based modeling

Juan R Cebral  1 , Fernando Mut, Marcelo Raschi, Yong-Hong Ding, Ramanathan Kadirvel, David Kallmes
Affiliations

Strategy for analysis of flow diverting devices based on multi-modality image-based modeling

Juan R Cebral et al. Int J Numer Method Biomed Eng. 2014 Oct.

Abstract

Quantification and characterization of the hemodynamic environment created after flow diversion treatment of cerebral aneurysms is important to understand the effects of flow diverters and their interactions with the biology of the aneurysm wall and the thrombosis process that takes place subsequently. This paper describes the construction of multi-modality image-based subject-specific CFD models of experimentally created aneurysms in rabbits and subsequently treated with flow diverters. Briefly, anatomical models were constructed from 3D rotational angiography images, flow conditions were derived from Doppler ultrasound measurements, stent models were created and virtually deployed, and the results were compared with in vivo digital subtraction angiography and Doppler ultrasound images. The models were capable of reproducing in vivo observations, including velocity waveforms measured in the parent artery, peak velocity values measured in the aneurysm, and flow structures observed with digital subtraction angiography before and after deployment of flow diverters. The results indicate that regions of aneurysm occlusion after flow diversion coincide with slow and smooth flow patterns, whereas regions still permeable at the time of animal sacrifice were observed in parts of the aneurysm exposed to larger flow activity, that is, higher velocities, more swirling, and more complex flow structures.

Keywords: CFD; cerebral aneurysm; flow diversion; hemodynamics; rabbit model.

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Figures

Figure 1
Figure 1
Image-based modeling.
Figure 2
Figure 2
Virtual stent deployment.
Figure 3
Figure 3
Flow estimation from Doppler ultrasound.
Figure 4
Figure 4
Flow splits and boundary conditions.
Figure 5
Figure 5
Estimation of occluded and permeable regions.
Figure 6
Figure 6
Doppler ultrasound and virtual ultrasound probes in the proximal parent artery.
Figure 7
Figure 7
Doppler ultrasound and CFD velocity profiles at the aneurysm orifice.
Figure 8
Figure 8
Virtual stent models and excised aneurysms with implanted stents.
Figure 9
Figure 9
comparison of DSA and CFD prior to treatment.
Figure 10
Figure 10
Comparison of DSA and CFD after stenting.
Figure 11
Figure 11
Comparison of DSA and CFD prior to treatment.
Figure 12
Figure 12
Comparison of DSA and CFD after stenting.
Figure 13
Figure 13
Flow patterns and occlusion regions.
See this image and copyright information in PMC

References

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    1. Cebral JR, et al. Aneurysm Rupture Following Treatment with Flow-Diverting Stents: Computational Hemodynamics Analysis of Treatment. AJNR American Journal of Neuroradiology. 2011;32(1):27–33. - PMC - PubMed

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