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. 2014 Oct 1;210(7):1047-51.
doi: 10.1093/infdis/jiu214. Epub 2014 Apr 8.

HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A

Nicolas Vince  1 , Arman A Bashirova  1 , Alexandra Lied  2 , Xiaojiang Gao  3 , Lucy Dorrell  4 , Paul J McLaren  5 , Jacques Fellay  5 , Mary Carrington  1
Affiliations

HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A

Nicolas Vince et al. J Infect Dis. .

Abstract

A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.

Keywords: HESN; HIV-1; HLA; KIR; hemophilia.

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References

    1. Franchini M, Mannucci PM. Hemophilia A in the third millennium. Blood Rev. 2013;27:179–84. - PubMed
    1. Kroner BL, Rosenberg PS, Aledort LM, Alvord WG, Goedert JJ. HIV-1 infection incidence among persons with hemophilia in the United States and western Europe, 1978-1990. Multicenter Hemophilia Cohort Study. J Acquir Immune Defic Syndr. 1994;7:279–86. - PubMed
    1. Horton RE, McLaren PJ, Fowke K, Kimani J, Ball TB. Cohorts for the study of HIV-1-exposed but uninfected individuals: benefits and limitations. J Infect Dis. 2010;202(Suppl 3):S377–81. - PubMed
    1. Arenzana-Seisdedos F, Parmentier M. Genetics of resistance to HIV infection: role of co-receptors and co-receptor ligands. Semin Immunol. 2006;18:387–403. - PubMed
    1. Lane J, McLaren PJ, Dorrell L, et al. A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Hum Mol Genet. 2013;22:1903–10. - PMC - PubMed

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