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. 2014:2014:480201.
doi: 10.1155/2014/480201. Epub 2014 Feb 27.

Human paraoxonase-1 activity is related to the number of CD4+ T-cells and is restored by antiretroviral therapy in HIV-1-infected individuals

Luciana Morganti Ferreira Maselli  1 , Joel da Cunha  2 , Eliana Battaggia Gutierrez  3 , Raul Cavalcante Maranhão  4 , Celso Spada  5 , Sérgio Paulo Bydlowski  6
Affiliations

Human paraoxonase-1 activity is related to the number of CD4+ T-cells and is restored by antiretroviral therapy in HIV-1-infected individuals

Luciana Morganti Ferreira Maselli et al. Dis Markers. 2014.

Abstract

Background: Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART).

Methods: PON1 activity was evaluated in 91 HIV-1 seronegative and 624 HIV-1 infected individuals (115 were not undergoing therapy (ART-naïve), and 509 were receiving HAART). HIV-1 infected individuals were treated with the following: efavirenz (EFV; n = 195) or nevirapine (NVP; n = 95) or lopinavir/ritonavir (LOP/r; n = 219). Serum levels of total cholesterol (TC), HDL, and low-density lipoprotein (LDL) fractions and the atherogenic indices (AI, TC : HDL, and LDL : HDL ratios) were determined.

Results: PON1 activity (U/L) was lower in the ART-naïve group compared with the other groups. PON1 activity correlated with CD4+ T-cell number of ART-naïve group (r = 0,121; P = 0,014). The LOP/r group showed a reduction in HDL and an increase in AI (TC : HDL ratio) in comparison with other groups.

Conclusion: PON1 activity was reduced in untreated individuals, but not in individuals receiving HAART. PON1 activity correlated with the number of CD4+ T-cells. The findings suggest that the activity of PON1 is associated with the immune status of HIV-1 infected individuals.

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References

    1. Riddler SA, Li X, Chu H, et al. Longitudinal changes in serum lipids among HIV-infected men on highly active antiretroviral therapy. HIV Medicine. 2007;8(5):280–287. - PubMed
    1. Stein JH, Komarow L, Cotter BR, et al. Lipoprotein changes in HIV-infected antiretroviral-naïve individuals after starting antiretroviral therapy: ACTG Study A5152s. Journal of Clinical Lipidology. 2008;2(6):464–471. - PMC - PubMed
    1. Negredo E, Paredes R, Peraire J, et al. Alternation of antiretroviral drug regimens for HIV infection. Efficacy, safety and tolerability at week 96 of the Swatch Study. Antiviral Therapy. 2004;9(6):889–893. - PubMed
    1. Wang X, Chai H, Yao Q, Chen C. Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction. Journal of Acquired Immune Deficiency Syndromes. 2007;44(5):493–499. - PubMed
    1. Hui DY. Effects of HIV protease inhibitor therapy on lipid metabolism. Progress in Lipid Research. 2003;42(2):81–92. - PubMed

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