Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Oct;18(4):277-91.
doi: 10.5863/1551-6776-18.4.277.

A review on vitamin d deficiency treatment in pediatric patients

Ji Yeon Lee  1 , Tsz-Yin So  2 , Jennifer Thackray  3
Affiliations
Review

A review on vitamin d deficiency treatment in pediatric patients

Ji Yeon Lee et al. J Pediatr Pharmacol Ther. 2013 Oct.

Abstract

Vitamin D is essential for calcium absorption and for maintaining bone health in the pediatric population. Vitamin D deficiency may develop from nutritional deficiencies, malabsorption, enzyme-inducing medications, and many other etiologies. It may present as hypocalcemia before bone demineralization at periods of increased growth velocity (infancy and adolescence) because the increased calcium demand of the body cannot be met. In children, inadequate concentrations of vitamin D may cause rickets and/or symptomatic hypocalcemia, such as seizures or tetany. In this review, we will discuss the pharmacology behind vitamin D supplementation, laboratory assessments of vitamin D status, current literature concerning vitamin D supplementation, and various supplementation options for the treatment of vitamin D deficiency in the pediatric population.

Keywords: cholecalciferol; ergocalciferol; pediatric; vitamin D deficiency.

PubMed Disclaimer

Figures

Figure.
Figure.
Vitamin D metabolism.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Misra M, Pacaud D, Petryk A et al. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122(2):398–417. - PubMed
    1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281. - PubMed
    1. Zhou C, Assem M, Tay JC et al. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest. 2006;116(6):1703–1712. - PMC - PubMed
    1. Fraser DR. Vitamin D. Lancet. 1995;345(8942):104–107. - PubMed
    1. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004;80(suppl 6):1689S–1696S. - PubMed

LinkOut - more resources