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. 2014;7(1):40-5.
doi: 10.3400/avd.oa.13-00092. Epub 2014 Feb 28.

Beraprost sodium for chronic diabetic foot ulcer: a randomized controlled trial in thammasat university hospital

Surajit Awsakulsutthi  1 , Kwanjit Punpho  2 , Jinpitcha Mamom  3 , Pairat Baikrut  4 , Patcharee Yingchoorod  4
Affiliations

Beraprost sodium for chronic diabetic foot ulcer: a randomized controlled trial in thammasat university hospital

Surajit Awsakulsutthi et al. Ann Vasc Dis. 2014.

Abstract

Background: Chronic diabetic foot ulcer has a high rate of healing failure. Beraprost sodium, oral form of prostaglandin I2 analogue, maybe used for increasing wound healing.

Objective: To compare the healing rate of chronic diabetic foot ulcer between Beraprost sodium and control groups.

Design: A single blind randomized trial.

Materials and methods: Fifty non-healed chronic diabetic foot ulcer patients were randomized to be the study and control groups. Beraprost sodium was prescribed in the study group according to protocol.

Results: At 6th week follow up, median wound healing rate in the study group was significantly higher than in the control group with the rate of 88.1% and 33.3%, respectively. Complete wound healing in the study group was also significantly higher than in the control group (48%:8%). In the study group, 9 patients (37.5%) could be administered with recommended dose. Side effects were headache in 14 patients (58.3%) and palpitation in one patient (4.2%). One patient was discontinued for severe headache.

Conclusions: The use of Beraprost sodium in chronic diabetic foot ulcer patients significantly increases the wound healing rate. Headache was the common side effect.

Keywords: Beraprost sodium; PG I2 analogue; chronic diabetic foot ulcer.

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Figures

Fig. 1
Fig. 1
Wound healing after used beraprost sodium at 0, 2nd, 6th week.
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