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. 2014 Jan;16(1):e11175.
doi: 10.5812/ircmj.11175. Epub 2014 Jan 5.

Resolving Vitamin D Deficiency in the Preconception Period among High-Risk Reproductive Women: A Randomized Controlled Trial

Mahshid Taheri  1 , Azam Baheiraei  2 , Abbas Rahimi Foroushani  3 , Maryam Modarres  4
Affiliations

Resolving Vitamin D Deficiency in the Preconception Period among High-Risk Reproductive Women: A Randomized Controlled Trial

Mahshid Taheri et al. Iran Red Crescent Med J. 2014 Jan.

Abstract

Background: Although vitamin D deficiency has been linked to potential complications in reproductive women, the recommended intake dosage of this vitamin in populations with high incidence of deficiency in preconception period has not been defined.

Objectives: The study investigated the effect of consuming a dosage of 2000 IU/day oral vitamin D for 105 days, on serum levels of this vitamin in reproductive women.

Materials and methods: 229 women with 18-35 years old, who were confirmed to be vitamin D deficient (vitamin D < 75 nmol/L), were randomized into the intervention and control groups and after 15 weeks consumption of the supplement and placebo, their serum samples were obtained.

Results: At baseline the mean serum levels of vitamin D in the control group was 23.34 ± 15.87 nmol/L and in intervention group was 25.13 ± 18.46 nmol/L, that these values didn't have any significant difference (P = 0.43), while after intervention, significant differences between the two groups was noticed (P < 0.001). The affecting factors to achieve normal range of vitamin D in the intervention group included basal amounts of vitamin D and two underlying factors based on questionnaire data: use of oral supplements (except vitamin D and calcium) in daily life and perfect sun exposure.

Conclusion: This study showed positive effect of the 2000 IU/day oral vitamin D on the serum level elevation of this vitamin in reproductive women.

Keywords: Dietary Supplements; Preconception; Vitamin D Deficiency.

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Figures

Figure 1.
Figure 1.. Consort Flow Diagram of Participants
* vitamin
Figure 2.
Figure 2.. Before Intervention Serum levels of Vitamin D in Both Group Represented the Vitamin D Deficiency But at the End of Trial More Than Half of Samples in Intervention Group had Normal Status
See this image and copyright information in PMC

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