Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:273932.
doi: 10.1155/2014/273932. Epub 2014 Feb 26.

Fetus sound stimulation: cilia memristor effect of signal transduction

Affiliations

Fetus sound stimulation: cilia memristor effect of signal transduction

Svetlana Jankovic-Raznatovic et al. Biomed Res Int. 2014.

Abstract

Background: This experimental study evaluates fetal middle cerebral artery (MCA) circulation after the defined prenatal acoustical stimulation (PAS) and the role of cilia in hearing and memory and could explain signal transduction and memory according to cilia optical-acoustical properties.

Methods: PAS was performed twice on 119 no-risk term pregnancies. We analyzed fetal MCA circulation before, after first and second PAS.

Results: Analysis of the Pulsatility index basic (PIB) and before PAS and Pulsatility index reactive after the first PAS (PIR 1) shows high statistical difference, representing high influence on the brain circulation. Analysis of PIB and Pulsatility index reactive after the second PAS (PIR 2) shows no statistical difference. Cilia as nanoscale structure possess magnetic flux linkage that depends on the amount of charge that has passed between two-terminal variable resistors of cilia. Microtubule resistance, as a function of the current through and voltage across the structure, leads to appearance of cilia memory with the "memristor" property.

Conclusion: Acoustical and optical cilia properties play crucial role in hearing and memory processes. We suggest that fetuses are getting used to sound, developing a kind of memory patterns, considering acoustical and electromagnetically waves and involving cilia and microtubules and try to explain signal transduction.

PubMed Disclaimer

Figures

Figure 1
Figure 1
RCLM (resistance, capacitance, inductance, memory) circuit system plays crucial role in cilia dynamics (microtubules, water interaction). dv: Rdi: resistance, dq: C dv: capacitance, : Ldi: inductance, and : M dq: memory.
Figure 2
Figure 2
PIB and PIR 1 of fetal MCA values. PIB: Pulsatile index basic; PIR 1: Pulsatile index reactive after first sound stimulation.
Figure 3
Figure 3
PIB and PIR 2 of fetal MCA values. PIB: Pulsatile index basic; PIR 2: Pulsatile index reactive after second sound stimulation.

References

    1. Dobrijević LJ, Ljubić A, Sovilj M, Ribarić-Jankes K, Miković Ž, Cerović N. Changes in Doppler blood flow velocity in middle cerebral artery in response to airborne sound in low- and high-risk human fetuses. International Journal of Pediatric Otorhinolaryngology. 2009;73(10):1381–1384. - PubMed
    1. Sovilj M, Ljubic A, Milenkovic V, Djokovic S. Possibilities of prenatal examination of fetal reactions on acoustical stimulation of fetuses with congenital infections. Proceedings of the 10th Symposium of Perinatal Medicine SLD; 1992; Belgrade, Serbia. pp. 17–18.
    1. Kierszenbaum AL. Histology and Cell Biology, An Introduction to Pathology. St. Louis, Mo, USA: Mosby; 2002.
    1. Lin X. Perception of sound and gravity by TMC1 and TMC2. Journal of Clinical Investigation. 2011;121(12):4633–4636. - PMC - PubMed
    1. Rachel RA, May-Simera HL, Veleri S, et al. Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis. Journal of Clinical Investigation. 2012;122(4):1233–1245. - PMC - PubMed

Publication types

LinkOut - more resources