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. 2014:2014:480573.
doi: 10.1155/2014/480573. Epub 2014 Feb 25.

A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma

Boris Léonard  1 , Frederic Kridelka  2 , Katty Delbecque  1 , Frederic Goffin  2 , Stéphanie Demoulin  3 , Jean Doyen  2 , Philippe Delvenne  1
Affiliations

A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma

Boris Léonard et al. Biomed Res Int. 2014.

Abstract

Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes of human papillomavirus (HPV). Vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma have different etiopathogenic pathways and are related or not with high risk HPV types. The goal of this paper is to review the main pathological and clinical features of these lesions. A special attention has been paid also to epidemiological data, pathological classification, and clinical implications of these diseases.

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Figures

Figure 1
Figure 1
Vulvar condyloma acuminatum with acanthotic squamous epithelium and prominent koilocytic changes.
Figure 2
Figure 2
Differentiated VIN developed on sclerous lichen: white and surelevated nodules.
Figure 3
Figure 3
uVIN 3, basaloid type composed of a homogeneous population of dysplastic parabasal type cells on nearly whole thickness of the epidermis.
Figure 4
Figure 4
Differentiated VIN: atypical keratinocytes (with large vesicular nuclei with macronucleoli), present in the basal as well as mid layers of the epithelium. No koilocytic changes are identified.
Figure 5
Figure 5
Exophytic and ulcerated squamous cell carcinoma.
Figure 6
Figure 6
Keratinizing squamous cell carcinoma: infiltrative neoplastic cells are mature with abundant eosinophilic cytoplasm and show keratin pearls.
See this image and copyright information in PMC

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