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. 2014 Sep;142(9):1848-58.
doi: 10.1017/S0950268814000831. Epub 2014 Apr 10.

Factors associated with diarrhoea in young children and incidence of symptomatic rotavirus infection in rural West Bengal, India

S Panda  1 , A K Deb  1 , M Chawla-Sarkar  1 , T Ramamurthy  1 , S Ganguly  1 , P Pradhan  1 , A Chakraborty  1 , S Desai  2 , M D Gupte  2 , R Dhere  2
Affiliations

Factors associated with diarrhoea in young children and incidence of symptomatic rotavirus infection in rural West Bengal, India

S Panda et al. Epidemiol Infect. 2014 Sep.

Abstract

Socio-behavioural factors and pathogens associated with childhood diarrhoea are of global public health concern. Our survey in 696 children aged ⩽2 years in rural West Bengal detected rotavirus as sole pathogen in 8% (17/199) of diarrhoeic stool specimens. Other organisms were detected along with rotavirus in 11% of faecal specimens. A third of the children with rotavirus diarrhoea, according to Vesikari score, had severe illness. The top four rotavirus genotypes were G9P[4] (28%), G1P[8] (19%), G2P[4] (14%) and G8P[4] (8%). In the multivariate model, the practice of 'drawing drinking water by dipping a pot in the storage vessel' [adjusted odds ratio (aOR) 2·21, 95% confidence interval (CI) 1·03-4·74, P = 0·041], and 'children aged ⩽6 months with non-exclusive breastfeeding' (aOR 2·07, 95% CI 1·1-3·82, P = 0·024) had twice the odds of having diarrhoea. Incidence of rotavirus diarrhoea was 24/100 child-years in children aged >6-18 months, 19/100 child-years in children aged >18-24 months and 5/100 child-years in those aged ⩽6 months. Results have translational implications for future interventions including vaccine development.

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Figures

Fig. 1.
Fig. 1.
Distribution of organisms in diarrhoea cases in different age groups.
See this image and copyright information in PMC

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