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Randomized Controlled Trial
. 2014 May;9(5):936-42.
doi: 10.2215/CJN.07170713. Epub 2014 Apr 10.

Effects of frequent hemodialysis on perceived caregiver burden in the Frequent Hemodialysis Network trials

Rita S Suri  1 , Brett Larive, Yoshio Hall, Paul L Kimmel, Alan S Kliger, Nathan Levin, Manjula Kurella Tamura, Glenn M Chertow; Frequent Hemodialysis Network (FHN) Trial Group
Affiliations
Randomized Controlled Trial

Effects of frequent hemodialysis on perceived caregiver burden in the Frequent Hemodialysis Network trials

Rita S Suri et al. Clin J Am Soc Nephrol. 2014 May.

Abstract

Background and objectives: Patients receiving hemodialysis often perceive their caregivers are overburdened. We hypothesize that increasing hemodialysis frequency would result in higher patient perceptions of burden on their unpaid caregivers.

Design, setting, participants, & measurements: In two separate trials, 245 patients were randomized to receive in-center daily hemodialysis (6 days/week) or conventional hemodialysis (3 days/week) while 87 patients were randomized to receive home nocturnal hemodialysis (6 nights/week) or home conventional hemodialysis for 12 months. Changes in overall mean scores over time in the 10-question Cousineau perceived burden scale were compared.

Results: In total, 173 of 245 (70%) and 80 of 87 (92%) randomized patients in the Daily and Nocturnal Trials, respectively, reported having an unpaid caregiver at baseline or during follow-up. Relative to in-center conventional dialysis, the 12-month change in mean perceived burden score with in-center daily hemodialysis was -2.1 (95% confidence interval, -9.4 to +5.3; P=0.58). Relative to home conventional dialysis, the 12-month change in mean perceived burden score with home nocturnal dialysis was +6.1 (95% confidence interval, -0.8 to +13.1; P=0.08). After multiple imputation for missing data in the Nocturnal Trial, the relative difference between home nocturnal and home conventional hemodialysis was +9.4 (95% confidence interval, +0.55 to +18.3; P=0.04). In the Nocturnal Trial, changes in perceived burden were inversely correlated with adherence to dialysis treatments (Pearson r=-0.35; P=0.02).

Conclusion: Relative to conventional hemodialysis, in-center daily hemodialysis did not result in higher perceptions of caregiver burden. There was a trend to higher perceived caregiver burden among patients randomized to home nocturnal hemodialysis. These findings may have implications for the adoption of and adherence to frequent nocturnal hemodialysis.

Keywords: daily hemodialysis; outcomes; randomized controlled trials.

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Figures

Figure 1.
Figure 1.
Flowchart of participants. Bold text indicates those participants included in the final analytic cohort. F, months after randomization. B, baseline.
Figure 2.
Figure 2.
Changes in perceived Cousineau score over time in the (A) Daily Trial and (B) Nocturnal Trial. Y axis indicates mean change in Cousineau burden score. 95% CI, 95% confidence interval.
See this image and copyright information in PMC

Comment in

  • Caregiver burden and hemodialysis.
    Cohen LM, Germain MJ. Cohen LM, et al. Clin J Am Soc Nephrol. 2014 May;9(5):840-2. doi: 10.2215/CJN.02690314. Epub 2014 Apr 10. Clin J Am Soc Nephrol. 2014. PMID: 24721889 Free PMC article. No abstract available.

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