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. 2014 May;41(5):290-1.
doi: 10.1097/OLQ.0000000000000123.

High-dose vaginal maintenance metronidazole for recurrent bacterial vaginosis: a pilot study

Tina Aguin  1 , Robert A Akins, Jack D Sobel
Affiliations

High-dose vaginal maintenance metronidazole for recurrent bacterial vaginosis: a pilot study

Tina Aguin et al. Sex Transm Dis. 2014 May.

Abstract

The purpose of this study was to explore the benefit of high-dose intravaginal metronidazole as a maintenance therapy in reducing recurrence rates of bacterial vaginosis (BV). Eighteen women with a history of recurrent BV and symptomatic BV were treated with metronidazole 750 mg suppository intravaginally daily for 7 days. Those in remission by Amsel criteria received metronidazole 750 mg twice weekly for 3 months with further follow-up for 3 months. High-dose metronidazole intravaginally was associated with rare clinical recurrence during the period of use. After cessation of suppression therapy, recurrence was high.

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