Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2014 Sep;173(9):1209-16.
doi: 10.1007/s00431-014-2308-4. Epub 2014 Apr 12.

Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy

Yvan Vandenplas  1 , Elisabeth De Greef, Bruno Hauser; Paradice Study Group
Collaborators, Affiliations
Clinical Trial

Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy

Yvan Vandenplas et al. Eur J Pediatr. 2014 Sep.

Abstract

Guidelines recommend the use of extensively hydrolyzed cow's milk protein-based formulas (eHF) in the treatment of infants with cow's milk protein allergy (CMPA). Extensively hydrolyzed rice protein infant formula (eRHF) has recently become available and could offer a valid alternative. A prospective trial was performed to evaluate the hypo-allergenicity and safety of a new eRHF in infants with a confirmed CMPA. Patients were fed the study formula for 6 months. Clinical tolerance of the eRHF was evaluated with a symptom-based score (SBS) and growth (weight and length) was monitored. Forty infants (mean age, 3.4 months; range, 1-6 months) with CMPA confirmed by a food challenge were enrolled. All infants tolerated the eRHF and the SBS significantly decreased as of the first month of intervention. Moreover, the eRHF allowed a catch-up to normal weight gain as of the first month as well as a normalization of the weight-for-age, weight-for length, and BMI z-scores within the 6-month study period.

Conclusion: In accordance with current guidelines, this eRHF was tolerated by more than 90 % of children with proven CMPA with a 95 % confidence interval. This eRHF is an adequate and safe alternative to cow milk-based eHF.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow chart
Fig. 2
Fig. 2
Evolution of weight-for-age z-score for boys and girls
See this image and copyright information in PMC

References

    1. Agostoni C, Axelsson I, Goulet O, ESPGHAN committee of Nutrition Soy protein infant formulae and follow on formulae a commentary by the ESPGHAN. J Pediatr Gastroenterol Nutr. 2006;42(4):352–361. doi: 10.1097/01.mpg.0000189358.38427.cd. - DOI - PubMed
    1. Agostoni C, Fiocchi A, Riva E, Terracciano L, Sarratud T, Martelli A, Lodi F, D’Auria E, Zuccotti G, Giovannini M. Growth of infants with IgE-mediated cow’s milk allergy fed different formulas in the complementary feeding period. Pediatr Allergy Immunol. 2007;18(7):599–606. doi: 10.1111/j.1399-3038.2007.00566.x. - DOI - PubMed
    1. American Academy of Pediatrics Committee on Nutrition. Hypoallergenic infant formula. Pediatrics. 2000;106(2Pt1):346–349. - PubMed
    1. Bhatia J, Greer F, American Academy of Pediatrics Committee on Nutrition Use of soy protein-based formulas in infant feeding. Pediatrics. 2008;121(5):1062–1068. doi: 10.1542/peds.2008-0564. - DOI - PubMed
    1. Commission Directive 98/83/EC on the quality of water intended for human consumption

Publication types

MeSH terms