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Review
. 2014 May;16(5):622-7.
doi: 10.1093/neuonc/nou049. Epub 2014 Apr 10.

Micro-masters of glioblastoma biology and therapy: increasingly recognized roles for microRNAs

Desiree Floyd  1 , Benjamin Purow
Affiliations
Review

Micro-masters of glioblastoma biology and therapy: increasingly recognized roles for microRNAs

Desiree Floyd et al. Neuro Oncol. 2014 May.

Abstract

MicroRNAs are small noncoding RNAs encoded in eukaryotic genomes that have been found to play critical roles in most biological processes, including cancer. This is true for glioblastoma, the most common and lethal primary brain tumor, for which microRNAs have been shown to strongly influence cell viability, stem cell characteristics, invasiveness, angiogenesis, metabolism, and immune evasion. Developing microRNAs as prognostic markers or as therapeutic agents is showing increasing promise and has potential to reach the clinic in the next several years. This succinct review summarizes current progress and future directions in this exciting and steadily expanding field.

Keywords: glioblastoma; microRNA; review.

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Figures

Fig. 1.
Fig. 1.
MicroRNA expression, processing, and function. RISC, RNA-induced silencing complex; Ran-GTP, Ras-related nuclear protein–guanosine triphosphate; TAR, HIV transactivation response.
Fig. 2.
Fig. 2.
PubMed citations with search terms “microRNA” and “glioblastoma” by year.
See this image and copyright information in PMC

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