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. 2014 Feb 26:2014:816545.
doi: 10.1155/2014/816545. eCollection 2014.

Effects of traditional Chinese medicine Shuxuetong injection on random skin flap survival in rats

Leyi Cai  1 , Wenfang Huang  2 , Dingsheng Lin  1
Affiliations

Effects of traditional Chinese medicine Shuxuetong injection on random skin flap survival in rats

Leyi Cai et al. ScientificWorldJournal. .

Abstract

Background: A Shuxuetong injection is traditionally used in Chinese medicine to treat "blood stasis and stagnation" (yu xue yu zhi). We investigated the effect of such injection on the survival of random skin flaps.

Methods: McFarlane flaps were established in 60 rats divided into two groups. Postoperative celiac injections were given to both groups for 7 days. Shuxuetong was injected into the test group, and saline was injected into controls. On day 7, tissues were stained with H&E (hematoxylin-eosin) stain, immunohistochemically evaluated, and the expression levels of xanthine oxidase were determined.

Result: The mean area of flap survival in the test group was significantly higher than in controls. Expression of vascular endothelial growth factor and superoxide dismutase, and microvessel development, were markedly increased in the test group, and the malondialdehyde level was reduced.

Conclusion: Shuxuetong promotes random skin flap survival.

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Figures

Figure 1
Figure 1
Digital photographs showing the general form of postoperative flaps in the Shuxuetong and control groups. The photographs were taken on days 3 and 7.
Figure 2
Figure 2
Histological changes in areas I, II, and III of flaps of the Shuxuetong and control groups. Magnifications: 100x and 400x. H&E stain.
Figure 3
Figure 3
The MVDs of areas I and II of the ShuXueTong and control groups.
Figure 4
Figure 4
VEGF protein levels in the Shuxuetong and control groups. (immunohistochemical staining) (×400).
Figure 5
Figure 5
SOD activities in the Shuxuetong and control groups.
Figure 6
Figure 6
MDA levels in the Shuxuetong and control groups.
See this image and copyright information in PMC

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