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Review
. 2014 Mar 16;5(5):301-10.
doi: 10.7150/jca.8610. eCollection 2014.

Investigating molecular profiles of ovarian cancer: an update on cancer stem cells

Federica Tomao  1 , Anselmo Papa  2 , Martina Strudel  2 , Luigi Rossi  2 , Giuseppe Lo Russo  2 , Pierluigi Benedetti Panici  1 , Francesca Romana Ciabatta  2 , Silverio Tomao  2
Affiliations
Review

Investigating molecular profiles of ovarian cancer: an update on cancer stem cells

Federica Tomao et al. J Cancer. .

Abstract

Currently we are more and more improving our knowledge about the characteristics and the role of cancer stem cells in human cancer. Particularly we have realized that self-renewing ovarian cancer stem cells (CSCs) or ovarian cancer-initiating cells, and mesenchymal stem cells (SCs) too, are probably implicated in the etiopathogenesis of epithelial ovarian cancer (EOC). There is clear evidence that these cells are also involved in its intra- and extra-peritoneal diffusion and in the occurrence of chemo-resistance. In assessing the molecular characteristics of ovarian CSCs, we have to take note that these cellular populations are rare and the absence of specific cell surface markers represents a challenge to isolate and identify pure SC populations. In our review, we focused our attention on the molecular characteristics of epithelial ovarian CSCs and on the methods to detect them starting from their biological features. The study of ovarian CSCs is taking on an increasingly important strategic role, mostly for the potential therapeutic application in the next future.

Keywords: Cancer stem cells markers; Epithelial ovarian cancer; Ovarian cancer stem cells; Therapeutic targets.; Tumor microenvironment.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Influence of CSC niche on biological processes of cancerogenesis. CAFs: Cancer-associated fibroblasts.
See this image and copyright information in PMC

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