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Review
. 2014 Mar 11;4(6):579-91.
doi: 10.7150/thno.7688. eCollection 2014.

Polysaccharide nanosystems for future progress in cardiovascular pathologies

Amanda Karine Andriola Silva  1 , Didier Letourneur  1 , Cédric Chauvierre  1
Affiliations
Review

Polysaccharide nanosystems for future progress in cardiovascular pathologies

Amanda Karine Andriola Silva et al. Theranostics. .

Abstract

Natural polysaccharides have received a lot of attention in the biomedical field. Indeed, sources of polysaccharides, extracted or produced from plants, bacteria, fungi or algae, are diverse and renewable. Moreover, recent progresses in polysaccharide chemistry and nanotechnologies allow elaborating new dedicated nanosystems. Polysaccharide-based nanosystems may be designed for interacting in several biological processes. In particular, the atherothrombotic pathology is highly concerned by polysaccharide-mediated recognition. Atherothrombotic diseases, regardless of the anatomical localization, remain the main causes of morbidity and mortality in the industrialized world. This review intends to provide an overview on polysaccharide-based nanosystems as drug delivery systems and targeted contrast agents for molecular imaging with an emphasis on the treatment and imaging of cardiovascular pathologies.

Keywords: Atherothrombosis; Drug delivery; Molecular imaging.; Nanosystems; Polysaccharides.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Polysaccharide molecular structures and some of their biological targets.
Figure 2
Figure 2
Physical properties and biological features of nanosystems considering their applications as drug carriers or imaging agents.
Figure 3
Figure 3
Advantages related to polysaccharide-based nanosystems considering their applications as drug carriers or imaging agents in atherothrombotic diseases.
Figure 4
Figure 4
Schematic representation of atherothrombotic lesion highlighting some key features involved in polysaccharide recognition: sialyl LewisX (1), heparin (2), fucoidan (3), cyclodextrin (4), chitosan (5) and hyaluronic acid (6).
See this image and copyright information in PMC

References

    1. Nitta SK, Numata K. Biopolymer-Based Nanoparticles for Drug/Gene Delivery and Tissue Engineering. Int. J. Mol. Sci. 2013;14:1629–54. - PMC - PubMed
    1. Oh JK, Lee DI, Park JM. Biopolymer-based microgels/nanogels for drug delivery applications. Prog. Polym. Sci. 2009;34:1261–82.
    1. Muthana SM, Campbell CT, Gildersleeve JC. Modifications of Glycans: Biological Significance and Therapeutic Opportunities. ACS Chem. Biol. 2012;7:31–43. - PMC - PubMed
    1. Sinha V, Kumria R. Polysaccharides in colon-specific drug delivery. Int. J. Pharm. 2001;224:19–38. - PubMed
    1. Quignard F, Di Renzo F, Guibal E. From natural polysaccharides to materials for catalysis, adsorption, and remediation. Top. Curr. Chem. 2010;294:165–97. - PubMed

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