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. 2014:2014:409837.
doi: 10.1155/2014/409837. Epub 2014 Mar 2.

Involvement of oxidative stress and inflammation in liver injury caused by perfluorooctanoic acid exposure in mice

Bei Yang  1 , Weiying Zou  1 , Zhenzhen Hu  2 , Fangming Liu  3 , Ling Zhou  4 , Shulong Yang  1 , Haibin Kuang  1 , Lei Wu  1 , Jie Wei  1 , Jinglei Wang  1 , Ting Zou  1 , Dalei Zhang  1
Affiliations

Involvement of oxidative stress and inflammation in liver injury caused by perfluorooctanoic acid exposure in mice

Bei Yang et al. Biomed Res Int. 2014.

Abstract

Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice.

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Figures

Figure 1
Figure 1
Relative liver weight after exposure to different concentrations of PFOA. Values are expressed as mean ± SEM (n = 4). Bars with different letters are statistically different (P < 0.05).
Figure 2
Figure 2
Liver histopathology after exposure to PFOA 0 (a), 2.5 (b), 5 (c), or 10 (d) mg/kg/day for 14 days. Sections of liver were stained with hematoxylin and eosin and then were visualized under an IX71 Olympus microscope. Magnification: 100x.
Figure 3
Figure 3
Serum levels of AST (a), ALT (b), ALP (c), LDH (d), and TBA (e) after exposure to different concentrations of PFOA. Values are expressed as mean ± SEM (n = 4). Bars with different letters are statistically different (P < 0.05).
Figure 4
Figure 4
Hepatic levels of MDA (a) and H2O2 (b) after exposure to different concentrations of PFOA. Values are expressed as mean ± SEM (n = 4). Bars with different letters are statistically different (P < 0.05).
Figure 5
Figure 5
Levels of CRP (a), IL-6 (b), and COX-2 (c) in liver tissue after exposure to different concentrations of PFOA. Values are expressed as mean ± SEM (n = 4). Bars with different letters are statistically different (P < 0.05).
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