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Review
. 2014 Apr:1311:57-76.
doi: 10.1111/nyas.12416.

Obesity and cancer pathogenesis

Nathan A Berger  1
Affiliations
Review

Obesity and cancer pathogenesis

Nathan A Berger. Ann N Y Acad Sci. 2014 Apr.

Abstract

Overweight and obesity have reached pandemic levels on a worldwide basis and are associated with increased risk and worse prognosis for many but not all malignancies. Pathophysiologic processes that affect this association are reviewed, with a focus on the relationship between type 2 diabetes mellitus and cancer, lessons learned from the use of murine models to study the association, the impact of obesity on pancreatic cancer, the effects of dietary fats and cholesterol on cancer promotion, and the mechanisms by which the intestinal microbiome affects obesity and cancer.

Keywords: cancer and obesity; cholesterol; diabetes; dietary fats; intestinal microbiome; murine models; pancreatic cancer.

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References

    1. Popkin BM. Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases. The American journal of clinical nutrition. 2006;84(2):289–98. - PubMed
    1. Popkin BM, Slining MM. New dynamics in global obesity facing low- and middle-income countries. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2013 Nov;14(Suppl 2):11–20. - PMC - PubMed
    1. Wang G-R, Li L, Pan Y-H, Tian G-D, Lin W-L, Li Z, Chen Z-Y, Gong Y-L, Kikano GE, Stange KC, Ni K-L, Berger NA. Prevalence of metabolic syndrome among urban community residents in China. BMC public health. 2013;13:599–599. - PMC - PubMed
    1. Ogden CL, Carroll MD, Kit BK, Flegal KM. NCHS data brief, no 82. Vol. 2012. National Center for Health Statistics; Hyattsville, MD: 2012. Prevalence of obesity in the United States, 2009–2010; pp. 1–8. - PubMed
    1. Ogden CL, Carroll MD, Kit BK, Flegal KM. NCHS data brief, no 131. NCHS data brief, no 82. Vol. 2013. National Center for Health Statistics; Hyattsville, MD: 2013. Prevalence of obesity among adults: United States, 2011–2012; pp. 1–8. - PubMed

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