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. 2014 Oct;36(10):894-6.
doi: 10.1179/1743132814Y.0000000376. Epub 2014 Apr 13.

Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population

Jianfang Ma, Yi Zhou, Jun Xu, Xiaohong Liu, Ying Wang, Yulei Deng, Gang Wang, Wei Xu, Rujin Ren, Xiaoying Liu, Yu Zhang, Cheng Wang, Huidong Tang, Shengdi Chen

Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population

Jianfang Ma et al. Neurol Res. 2014 Oct.

Abstract

Objective: We conducted a case-control study to investigate whether TREM2 polymorphism (rs75932628-T) was associated with late onset Alzheimer's disease in Chinese Southern Han population.

Methods: PCR-restriction fragment length polymorphism assay was performed to genotype rs75932628 in 279 cases with late onset Alzheimer's diseases patients and 346 control subjects in Shanghai and Nanjing.

Results: There was no rs75932628-T variant detected in our sample. However, APOEϵ4 was shown closely associated with the risk of Alzheimer's disease (Chi-square = 60·288, P = 0·000).

Conclusion: Our study suggested that TREM2 (rs75932628-T) was rare in Chinese Han population. Further association studies with large samples are needed to further study the association of TREM2 with late-onset Alzheimer's disease.

Keywords: Alzheimer’s disease; Polymorphism,; TREM2,; rs75932628,.

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